Ua ʻōlelo ʻia ke kelepona he homozygous no kekahi gene ke loaʻa nā alleles like o ka gene ma nā chromosomes homologous ʻelua.
ʻO ke kŘkohu ʻiole homozygous he holoholona lab i hoʻohana maʻamau ʻia i hoʻoponopono ʻia ma ke ʻano he ʻelua kope like o kahi gene kikoʻī.Hoʻohana nui ʻia kēia ʻano hoʻohālike i nā noiʻi ʻepekema e nānā i nā maʻi a me nā maʻi genetic like ʻole.
Me ka ʻenehana kuʻuna, pono ia ma kahi o 2-3 mau hanauna o ka hānau ʻana a me ka nānā ʻana no ka loaʻa ʻana o nā ʻiole homozygous mai nā ʻiole funder, ʻo ia ke kumu kūʻai o 10-12 mau mahina me nā uku kūleʻa haʻahaʻa.